Regulation of cell function by Rho family GTPases

Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effectors to modulate cell function...

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Veröffentlicht in:	Immunologic research 2000-01, Vol.21 (2-3), p.139-148
1. Verfasser:	Bokoch, G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cell Movement - physiology Cells Cytoskeleton - physiology Enzymes Humans Immunology Kinases Leukocytes rho GTP-Binding Proteins - physiology Rho protein Signal Transduction
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Beschreibung
Zusammenfassung:	Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effectors to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH oxidase regulation by Rac2, Rac- and Cdc42-mediated control of the actin-myosin cytoskeleton via p21-activated kinase (PAK), and modulation of the apoptotic program by Rho GTPases and PAK.
ISSN:	0257-277X 0257-277X 1559-0755
DOI:	10.1385/IR:21:2-3:139