New antiarrhythmic agents: a conceptually novel approach

Synthesis and biological evaluation of novel phenoxyalkyl amines exhibiting both class Ib and class III type electrophysiological properties are described. Two compounds showed excellent antiarrhythmic effects against reperfusion induced arrhythmias. © 2000 John Wiley & Sons, Inc. Med Res Rev, 2...

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Veröffentlicht in:	Medicinal research reviews 2000-07, Vol.20 (4), p.294-303
Hauptverfasser:	Mátyus, Péter, Rettegi, Tivadar, Varró, András, Papp, Julius Gy
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6‐dimethylphenoxyalkyl amines 6-dimethylphenoxyalkyl amines Amines - chemical synthesis Amines - chemistry Amines - pharmacology Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - pharmacology antiarrhythmic agents Antiarythmic agents Biological and medical sciences Cardiovascular system combination of antiarrhythmic mechanisms Dogs Female Guinea Pigs Heart - drug effects Heart - physiology In Vitro Techniques Magnetic Resonance Spectroscopy Male Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship
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Zusammenfassung:	Synthesis and biological evaluation of novel phenoxyalkyl amines exhibiting both class Ib and class III type electrophysiological properties are described. Two compounds showed excellent antiarrhythmic effects against reperfusion induced arrhythmias. © 2000 John Wiley & Sons, Inc. Med Res Rev, 20, No. 4, 294–303, 2000
ISSN:	0198-6325 1098-1128
DOI:	10.1002/1098-1128(200007)20:4<294::AID-MED2>3.0.CO;2-5