A common T/C polymorphism in the promoter region of the beta T-cell receptor gene

Polymorphisms in the T-cell receptor genes can provide important information for the study of the immune response system, particularly for autoimmune diseases. This report characterizes a common T to C polymorphism in the promoter of the beta 2 constant chain of the T-cell receptor, which abolishes...

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Veröffentlicht in:	Molecular and cellular probes 2000-06, Vol.14 (3), p.195-197
Hauptverfasser:	Tripputi, P, Graziani, D, Alfano, RM, Cassani, B, Coggi, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Bacterial Proteins Deoxyribonucleases, Type II Site-Specific - metabolism European Continental Ancestry Group - genetics Female Gene Frequency - genetics Genes, T-Cell Receptor beta - genetics Genotype Humans Male Mutation - genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length Promoter Regions, Genetic - genetics T-cell receptor, TCR beta, TCR polmorphism, Bgl II polymorphism
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Beschreibung
Zusammenfassung:	Polymorphisms in the T-cell receptor genes can provide important information for the study of the immune response system, particularly for autoimmune diseases. This report characterizes a common T to C polymorphism in the promoter of the beta 2 constant chain of the T-cell receptor, which abolishes a recognition site for Bgl II restriction endonuclease.
ISSN:	0890-8508 1096-1194
DOI:	10.1006/mcpr.2000.0301