An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy

A 32-year-old woman presenting with a rapidly progressive ALS-like syndrome was found to be HIV positive with a CD4 count of 44/mm(3). The patient recovered completely during 1 year after treatment with nelfinavir, zidovudine, and lamivudine, and recovery is sustained nearly 4 years later. Recovery...

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Veröffentlicht in:	Neurology 2001-09, Vol.57 (6), p.1094-1097
Hauptverfasser:	MACGOWAN, D. J. L, SCELSA, S. N, WALDRON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Biological and medical sciences Brain - pathology Drug Therapy, Combination Female Follow-Up Studies HIV Infections - diagnosis HIV Infections - drug therapy Human viral diseases Humans Infectious diseases Lamivudine - therapeutic use Magnetic Resonance Imaging Medical sciences Motor Neuron Disease - diagnosis Motor Neuron Disease - drug therapy Nelfinavir - therapeutic use Neurologic Examination - drug effects Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zidovudine - therapeutic use
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Beschreibung
Zusammenfassung:	A 32-year-old woman presenting with a rapidly progressive ALS-like syndrome was found to be HIV positive with a CD4 count of 44/mm(3). The patient recovered completely during 1 year after treatment with nelfinavir, zidovudine, and lamivudine, and recovery is sustained nearly 4 years later. Recovery was accompanied by HIV RNA becoming undetectable in plasma and CSF.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.57.6.1094