The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes

Varying concentrations of octreotide acetate (Sandostatin®) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37°C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37°C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.