Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326: I. Taxonomy, Fermentation, Isolation and Biological Activities

Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326: I. Taxonomy, Fermentation, Isolation and Biological Activities

Streptomyces sp. WK-6326, a soil isolate, was found to produce an inhibitor of interleukin (IL)-4 signal transduction. Two structurally related compounds, a novel one designated deacetylravidomycin M and the known deacetylravidomycin, were isolated from the culture broth by solvent extraction, silic...

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Veröffentlicht in:Journal of antibiotics 2001/07/25, Vol.54(7), pp.554-561
Hauptverfasser: ARAI, MASAYOSHI, TOMODA, HIROSHI, MATSUMOTO, ATSUKO, TAKAHASHI, YOKO, WOODRUFF, BODY H., ISHIGURO, NOBIKO, KOSAYASHI, SUSUMU, OMURA, SATOSHI
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacillus subtilis - drug effects
Biological and medical sciences
Cell Survival - drug effects
Chemotherapic agents
Fermentation
Fundamental and applied biological sciences. Psychology
Humans
Interleukin-4 - antagonists & inhibitors
Microbial Sensitivity Tests
Microbiology
Receptors, IgE
Signal Transduction - drug effects
Streptomyces - chemistry
Streptomyces - classification
Streptomyces - metabolism
U937 Cells
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Zusammenfassung:Streptomyces sp. WK-6326, a soil isolate, was found to produce an inhibitor of interleukin (IL)-4 signal transduction. Two structurally related compounds, a novel one designated deacetylravidomycin M and the known deacetylravidomycin, were isolated from the culture broth by solvent extraction, silica gel column chromatography and HPLC. Deacetylravidomycin M inhibited IL-4-induced CD23 expression in U937 cells without any cytotoxic effect, whereas deacetylravidomycin showed no inhibitory activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.554