Orbital and Dorsolateral Frontal Perfusion Defect Associated With Behavioral Response to Cholinesterase Inhibitor Therapy in Alzheimer's Disease

The authors retrospectively explored the behavioral and functional imaging profile of Alzheimer's disease (AD) patients who respond to cholinesterase inhibitor therapy by using the Neuropsychiatric Inventory (NPI) and baseline [99mTc]HMPAO SPECT. Thirty AD patients were divided into three group...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The journal of neuropsychiatry and clinical neurosciences 2000, Vol.12 (2), p.209-218
Hauptverfasser:	Mega, Michael S, Dinov, Ivo D, Lee, Linda, O'Connor, Susan M, Masterman, Donna M, Wilen, Barry, Mishkin, Fred, Toga, Arthur W, Cummings, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Behavior - drug effects Behavior - physiology Biological and medical sciences Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cholinesterase Inhibitors - therapeutic use Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Double-Blind Method Female Frontal Lobe - blood supply Frontal Lobe - diagnostic imaging Geriatrics Humans Image Processing, Computer-Assisted Male Medical sciences Neurology Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radionuclide Imaging Radiopharmaceuticals Technetium Tc 99m Exametazime Trichlorfon - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The authors retrospectively explored the behavioral and functional imaging profile of Alzheimer's disease (AD) patients who respond to cholinesterase inhibitor therapy by using the Neuropsychiatric Inventory (NPI) and baseline [99mTc]HMPAO SPECT. Thirty AD patients were divided into three groups (Responders, Nonresponders, and Unchanged) based on their behavioral response to donepezil. Responders had significantly (P≤0.01) more pretreatment irritability, disinhibition (P≤0.05), and euphoria (P=0.05) than Nonresponders and significantly lower lateral orbital frontal (P
ISSN:	0895-0172 1545-7222
DOI:	10.1176/jnp.12.2.209