Changes in liver fatty acid unsaturation after partial hepatectomy in the rat

The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between...

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Veröffentlicht in:	Lipids 2000-04, Vol.35 (4), p.445-452
Hauptverfasser:	Kishino, Tomonori, Tanno, Munehiko, Yamada, Hideo, Saito, Shozo, Matsumoto, Shigenobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - analysis Arachidonic Acid - metabolism Chromatography, Gas Diet Docosahexaenoic Acids - analysis Docosahexaenoic Acids - metabolism Fatty acids Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - metabolism Hepatectomy Kinetics Linoleic Acid - analysis Linoleic Acid - metabolism Liquid chromatography Liver Liver - chemistry Liver - metabolism Liver Regeneration - physiology Magnetic Resonance Spectroscopy Male NMR Nuclear magnetic resonance Nutrition Oleic Acid - analysis Oleic Acid - metabolism Polyunsaturated fatty acids Rats Rats, Wistar
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Zusammenfassung:	The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsaturation and fatty acid composition in the regenerating liver were also investigated in this study. Proton nuclear magnetic resonance spectroscopy revealed significantly elevated levels of unsaturation with a maximum on day 5 after partial hepatectomy, compared with untreated controls (11.72±0.55 vs. 11.05±0.26%, P
ISSN:	0024-4201 1558-9307
DOI:	10.1007/s11745-000-543-9