Homer: a link between neural activity and glutamate receptor function

The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current Opinion in Neurobiology 2000-06, Vol.10 (3), p.370-374
Hauptverfasser:	Xiao, Bo, Cheng Tu, Jian, Worley, Paul F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - physiology Ena/VASP homology domain Homer Homer protein Homer Scaffolding Proteins Humans Immediate early gene Neurons - physiology Neuropeptides - physiology receptor trafficking Receptors, Glutamate - physiology Synaptic Transmission - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/S0959-4388(00)00087-8