Influence of renal function on the pharmacokinetics of cerivastatin in normocholesterolemic adults

The influence of impaired renal function on the pharmacokinetics of single and multiple doses of cerivastatin was evaluated in this nonrandomized, non-blinded, 7-day, multiple-dose study. Thirty-five adults between the ages of 21 years and 75 years with normal renal function (CL(CR) >90 ml/min/1....

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Veröffentlicht in:	European journal of clinical pharmacology 2000-04, Vol.56 (1), p.69-74
Hauptverfasser:	MAZZU, A. L, LETTIERI, J. T, KELLY, E, VARGAS, R, MARBURY, T, LIU, M.-C, SUNDARESAN, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Area Under Curve Biological and medical sciences Drug therapy Female General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Male Medical research Medical sciences Middle Aged Pharmacology. Drug treatments Pyridines - administration & dosage Pyridines - blood Pyridines - pharmacokinetics Regression Analysis Renal Insufficiency - drug therapy Renal Insufficiency - metabolism
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Zusammenfassung:	The influence of impaired renal function on the pharmacokinetics of single and multiple doses of cerivastatin was evaluated in this nonrandomized, non-blinded, 7-day, multiple-dose study. Thirty-five adults between the ages of 21 years and 75 years with normal renal function (CL(CR) >90 ml/min/1.73 m2, n = 9), or patients with either mild (CL(CR) 61 ml/min/1.73 m2 to < or =90 ml/min/1.73 m2, n = 9), moderate (CL(CR) 30 ml/min/1.73 m2 to < or =60 ml/ min/1.73 m2, n = 8), or severe (CL(CR)
ISSN:	0031-6970 1432-1041
DOI:	10.1007/s002280050723