Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells

We report that 5-day exposure to physiological concentrations of eicosapentaenoic and docosahexaenoic acids resulted in a strong decrease in expression of the RIalpha regulatory subunit of protein kinase A and the PKC-alpha isozyme of protein kinase C in the human breast cancer cell line MDA-MB-231.

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Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research and treatment 2001-06, Vol.67 (3), p.279-283
Hauptverfasser:	MOORE, Nina G, WANG-JOHANNING, Feng, PI LING CHANG, JOHANNING, Gary L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acids - pharmacology Biological and medical sciences Breast cancer Breast Neoplasms - pathology Cancer research Cancer therapies Cyclic AMP-Dependent Protein Kinases - biosynthesis Docosahexaenoic Acids - pharmacology Female Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Isoenzymes Mammary gland diseases Medical sciences Protein Kinase C - biosynthesis Tumor Cells, Cultured Tumors
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Beschreibung
Zusammenfassung:	We report that 5-day exposure to physiological concentrations of eicosapentaenoic and docosahexaenoic acids resulted in a strong decrease in expression of the RIalpha regulatory subunit of protein kinase A and the PKC-alpha isozyme of protein kinase C in the human breast cancer cell line MDA-MB-231.
ISSN:	0167-6806 1573-7217
DOI:	10.1023/A:1017968029628