High circulating levels of soluble scavenger receptors (scd5 and sCD6) in patients with primary Sjögren's syndrome

To determine the existence of circulating levels of soluble scavenger receptors (sCD5 and sCD6) in patients with primary Sjögren's syndrome (SS), and to analyse the correlation with clinical and immunological features of SS. Ninety consecutive patients with primary SS were studied. All patients...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2001-09, Vol.40 (9), p.1056-1059
Hauptverfasser: RAMOS-CASALS, M, FONT, J, GARCIA-CARRASCO, M, CALVO, J, PLACES, L, PADILLA, O, CERVERA, R, BOWEN, M. A, LOZANO, F, INGELMO, M
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Sprache:eng
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Zusammenfassung:To determine the existence of circulating levels of soluble scavenger receptors (sCD5 and sCD6) in patients with primary Sjögren's syndrome (SS), and to analyse the correlation with clinical and immunological features of SS. Ninety consecutive patients with primary SS were studied. All patients fulfilled four or more of the European diagnostic criteria for SS. sCD5 and sCD6 levels were determined using a specific enzyme-linked immunosorbent assay (ELISA) developed in our laboratory. Detectable levels of sCD5 were found in 39 (43%) SS patients. The mean+/-standard error values of sCD5 were 3.5+/-0.5 ng/ml for patients with SS and 1.9+/-0.1 ng/ml for healthy blood donors (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/40.9.1056