Neuroprotective effect of retro-inverso Prosaptide D5 on focal cerebral ischemia in rat

Prosaposin (the precursor of saposins A-D) has been identified as a neurotrophic factor in vitro and in vivo. In this study, a novel 11-mer retro-inverso peptidomimetic, Prosaptide D5, was injected i.m. to assess its effectiveness in a rat ischemic model produced by reversible total occlusion of the...

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Veröffentlicht in:	Neuroreport 2000-06, Vol.11 (8), p.1791-1794
Hauptverfasser:	Lu, Ai Gang, Otero, Deborah A. C, Hiraiwa, Masao, OʼBrien, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Animals Biochemistry and metabolism Biological and medical sciences Brain Edema - pathology Brain Ischemia - pathology Central nervous system Cerebral Infarction - pathology Fundamental and applied biological sciences. Psychology Male middle cerebral artery Molecular Sequence Data Nerve Growth Factors - genetics Nerve Growth Factors - pharmacokinetics Nerve Growth Factors - pharmacology Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology prosaposin Rats Rats, Sprague-Dawley saposins Vertebrates: nervous system and sense organs
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Zusammenfassung:	Prosaposin (the precursor of saposins A-D) has been identified as a neurotrophic factor in vitro and in vivo. In this study, a novel 11-mer retro-inverso peptidomimetic, Prosaptide D5, was injected i.m. to assess its effectiveness in a rat ischemic model produced by reversible total occlusion of the left middle cerebral artery (MCA). Prosaptide (300 μg/kg, i.m.) injected 3 h after reversible occlusion reduced brain infarct area by 56% compared with a saline group (p
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200006050-00039