Evaluation of Protein S-100 serum concentrations in healthy newborns and seven newborns with perinatal acidosis

We measured Protein S‐100 serum levels in 66 healthy newborns during the first week of life and in 7 newborns with perinatal acidosis. Normal values (n= 66) constantly ranged between 0.66 and 3.33 ug/1 (2.5 and 97.5 percentiles) during the evaluation period. Conclusions: Newborns with signs of hypoxic‐ischaemic encephalopathy (HIE) after perinatal acidosis showed elevated Protein S‐100 serum levels, whereas newborns without these signs had normal concentrations. S‐100 might thus be a marker of central nervous system damage in newborns.