A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation

Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J....

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Veröffentlicht in:	FEBS letters 2001-09, Vol.505 (1), p.141-146
1. Verfasser:	Riman, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbonyldiphosphonate Deoxyribonucleotides - metabolism Diphosphonates - pharmacology DNA Polymerase I - metabolism DNA Polymerase II - antagonists & inhibitors DNA polymerase α DNA Primase - drug effects DNA Primase - metabolism DNA Primers - metabolism Enzyme Inhibitors - pharmacology Mimosine Mimosine - metabolism Primase Primer molecule Ribonucleotides - metabolism
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