A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation
Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J....
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| Veröffentlicht in: | FEBS letters 2001-09, Vol.505 (1), p.141-146 |
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| creator | Riman, J |
| description | Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Řı́man and A. Šulová, Acta Virol. 41 (1997) 181–214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol α, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed. |
| doi_str_mv | 10.1016/S0014-5793(01)02808-3 |
| format | Article |
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Řı́man and A. Šulová, Acta Virol. 41 (1997) 181–214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol α, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(01)02808-3</identifier><identifier>PMID: 11557057</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Carbonyldiphosphonate ; Deoxyribonucleotides - metabolism ; Diphosphonates - pharmacology ; DNA Polymerase I - metabolism ; DNA Polymerase II - antagonists & inhibitors ; DNA polymerase α ; DNA Primase - drug effects ; DNA Primase - metabolism ; DNA Primers - metabolism ; Enzyme Inhibitors - pharmacology ; Mimosine ; Mimosine - metabolism ; Primase ; Primer molecule ; Ribonucleotides - metabolism</subject><ispartof>FEBS letters, 2001-09, Vol.505 (1), p.141-146</ispartof><rights>2001 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(01)02808-3$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11557057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riman, J</creatorcontrib><title>A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Řı́man and A. Šulová, Acta Virol. 41 (1997) 181–214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol α, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.</description><subject>Carbonyldiphosphonate</subject><subject>Deoxyribonucleotides - metabolism</subject><subject>Diphosphonates - pharmacology</subject><subject>DNA Polymerase I - metabolism</subject><subject>DNA Polymerase II - antagonists & inhibitors</subject><subject>DNA polymerase α</subject><subject>DNA Primase - drug effects</subject><subject>DNA Primase - metabolism</subject><subject>DNA Primers - metabolism</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Mimosine</subject><subject>Mimosine - metabolism</subject><subject>Primase</subject><subject>Primer molecule</subject><subject>Ribonucleotides - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAUha2qVZlCH6GVV1W7SPGNE9uzQiP6KyFYAGvLiW80rhI72AliHqMP0-fglfAE6JbF9dWVv-Ofcwj5AOwrMBDHl4xBVdRyzT8z-MJKxVTBX5EVKMkLXgn1mqz-IwfkXUp_WJ4VrN-SA4C6lqyWK_J3Q7-db-gY-t2A0SSk9_-o81vXuClEatrJ3ZoJE522SKNrAjXeUovhbrdMQ7B5M3R0jG7Yy_FujJiSC34hnbdzmwlDZ-9uZqTjFn0YcvlnFe6vaedh7s2UZUfkTWf6hO-f-iG5_vH96vRXcXbx8_fp5qzAcl1NBYiqa6VQwsq1rTvOOgVGoeGiK1XdlFWjGmSqkUxiJkWdFytBYtkoUEbyQ_Lp8dwxhvywNOnBpRb73ngMc9ISQFYlEy-CoET2XNYZ_PgEzs2AVi-WxJ1-djsDJ48A5n_dOow6tQ59i9ZFbCdtg9PA9D5fveSr9-FpBnrJV3P-AEzCmcw</recordid><startdate>20010907</startdate><enddate>20010907</enddate><creator>Riman, J</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20010907</creationdate><title>A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation</title><author>Riman, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e294t-164fc7686d79d5f30f81a8ea36f285b24b8be08b707e4fc654fcd717e2b818a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Carbonyldiphosphonate</topic><topic>Deoxyribonucleotides - metabolism</topic><topic>Diphosphonates - pharmacology</topic><topic>DNA Polymerase I - metabolism</topic><topic>DNA Polymerase II - antagonists & inhibitors</topic><topic>DNA polymerase α</topic><topic>DNA Primase - drug effects</topic><topic>DNA Primase - metabolism</topic><topic>DNA Primers - metabolism</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Mimosine</topic><topic>Mimosine - metabolism</topic><topic>Primase</topic><topic>Primer molecule</topic><topic>Ribonucleotides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riman, J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riman, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2001-09-07</date><risdate>2001</risdate><volume>505</volume><issue>1</issue><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Řı́man and A. Šulová, Acta Virol. 41 (1997) 181–214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol α, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>11557057</pmid><doi>10.1016/S0014-5793(01)02808-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2001-09, Vol.505 (1), p.141-146 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | Wiley-Blackwell Journals; Wiley-Blackwell Open Access Backfiles; MEDLINE; Elsevier ScienceDirect Journals Complete; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Carbonyldiphosphonate Deoxyribonucleotides - metabolism Diphosphonates - pharmacology DNA Polymerase I - metabolism DNA Polymerase II - antagonists & inhibitors DNA polymerase α DNA Primase - drug effects DNA Primase - metabolism DNA Primers - metabolism Enzyme Inhibitors - pharmacology Mimosine Mimosine - metabolism Primase Primer molecule Ribonucleotides - metabolism |
| title | A DNA polymerase ϵ inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation |
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