A General Synthesis of Structurally Diverse Building Blocks for Preparing Analogues of C-Linked Antifreeze Glycoproteins

A synthetic methodology to afford unusual glycoconjugate building blocks useful for the solid-phase synthesis of C-linked antifreeze glycoprotein (AFGP) analogues is described. Such compounds are urgently required in order to elucidate the molecular mechanism by which AFGPs function. All reactions a...

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Veröffentlicht in:Bioconjugate chemistry 2001-09, Vol.12 (5), p.817-823
Hauptverfasser: Eniade, Adewale, Murphy, Anastasia V, Landreau, Geraldine, Ben, Robert N
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Sprache:eng
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Zusammenfassung:A synthetic methodology to afford unusual glycoconjugate building blocks useful for the solid-phase synthesis of C-linked antifreeze glycoprotein (AFGP) analogues is described. Such compounds are urgently required in order to elucidate the molecular mechanism by which AFGPs function. All reactions are general in nature and accommodate structural variation in the carbohydrate moiety, polypeptide backbone, and amino acid side chain.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc0155059