Secretin and Autism: A Two-Part Clinical Investigation

Fifty-six children with either autism or pervasive developmental disorders not otherwise specified received one injection of secretin, a gastrointestinal hormone. Re-evaluation 3-6 weeks later found minimal but potentially significant improvements, including changes in gastrointestinal symptoms, exp...

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Veröffentlicht in:	Journal of autism and developmental disorders 2000-04, Vol.30 (2), p.87-98
Hauptverfasser:	Chez, Michael G, Buchanan, Cathleen P, Bagan, Bradley T, Hammer, Michael S, McCarthy, Karla S, Ovrutskaya, Irina, Nowinski, Carlynn V, Cohen, Zamia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anatomy Authors Autism Autism Spectrum Disorders Autistic Disorder - diagnosis Autistic Disorder - drug therapy Autistic young children Behavior Change Behavior Patterns Child Child, Preschool Children Clinical trials Control Groups Developmental Disabilities Double-Blind Method Drug Therapy Female Follow-Up Studies Hormones Humans Hyperactivity Injections, Intravenous Male Motor Vehicles Outcomes of Treatment Parents Patients Periodicals Pervasive Developmental Disorders Rating Scales Receptive Language Secretin Secretin - adverse effects Secretin - therapeutic use Treatment Treatment Outcome
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Zusammenfassung:	Fifty-six children with either autism or pervasive developmental disorders not otherwise specified received one injection of secretin, a gastrointestinal hormone. Re-evaluation 3-6 weeks later found minimal but potentially significant improvements, including changes in gastrointestinal symptoms, expressive and/or receptive language function, and improved awareness and social interaction. A second double-blind study with 17 children found few clinically meaningful changes. (Contains references.) (Author/DB)
ISSN:	0162-3257 1573-3432
DOI:	10.1023/a:1005443119324