Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1

Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1

Tetramethylrosamine (TMR) is excluded from P‐glycoprotein (MDR1)‐enriched cell lines, but it stains efficiently MDR1‐poor parent lines. Application of the TMR resistance assay to cells obtained from chronic myelogenous leukaemia (CML) patients revealed, in all individuals, a significant resistance c...

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Veröffentlicht in:British journal of haematology 2001-09, Vol.114 (3), p.581-590
Hauptverfasser: Carter, Anne, Dann, Eldad J., Katz, Tamar, Shechter, Yael, Oliven, Ana, Regev, R., Eytan, Esther, Rowe, Jacob M., Eytan, Gera D.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antineoplastic agents
ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics
ATP-Binding Cassette Transporters - genetics
Biological and medical sciences
Case-Control Studies
Chemotherapy
chronic myelogenous leukaemia
Dihydrolipoyllysine-Residue Acetyltransferase
Doxorubicin
Drug Resistance, Multiple
Fungal Proteins - genetics
Genes, MDR
Hematology
Heterocyclic Compounds, 3-Ring
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism
MDR1
Medical sciences
MRP1
multidrug resistance
Multidrug Resistance-Associated Proteins
Pharmacology. Drug treatments
Pyruvate Dehydrogenase Complex
Reverse Transcriptase Polymerase Chain Reaction
Rhodamine 123
Ribosomal Proteins - genetics
RNA, Messenger - analysis
Transcription, Genetic
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Zusammenfassung:Tetramethylrosamine (TMR) is excluded from P‐glycoprotein (MDR1)‐enriched cell lines, but it stains efficiently MDR1‐poor parent lines. Application of the TMR resistance assay to cells obtained from chronic myelogenous leukaemia (CML) patients revealed, in all individuals, a significant resistance compared with healthy donors (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02969.x