DIFFERENCES IN THE GENOTYPES AND PLASMA CONCENTRATIONS OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST IN BLACK AND WHITE SOUTH AFRICAN ASTHMATICS AND CONTROL SUBJECTS

The allelic frequency of a variable tandem repeat (VNTR) polymorphism in intron 2 of the IL-1 Ra gene was studied in black and white patients with asthma as well as control individuals. The plasma IL-1 Ra concentration was also determined in asthmatics and compared to control individuals. The 410-bp...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2000-06, Vol.12 (6), p.819-821
Hauptverfasser:	Pillay, Visva, Gaillard, Marie-Christine, Halkas, Andrew, Song, Ernest, Dewar, John B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Continental Ancestry Group - genetics Asthma - blood Asthma - genetics Asthma - immunology asthma/interluekin 1 receptor antagonist/polymorphism Child Child, Preschool European Continental Ancestry Group - genetics Genotype Humans Interleukin 1 Receptor Antagonist Protein Introns Middle Aged Minisatellite Repeats Receptors, Interleukin-1 - antagonists & inhibitors Reference Values Sialoglycoproteins - blood Sialoglycoproteins - genetics South Africa
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Zusammenfassung:	The allelic frequency of a variable tandem repeat (VNTR) polymorphism in intron 2 of the IL-1 Ra gene was studied in black and white patients with asthma as well as control individuals. The plasma IL-1 Ra concentration was also determined in asthmatics and compared to control individuals. The 410-bp allele of the IL-1 Ra was significantly increased in all black subjects (90%) as compared to all white subjects (74%, P
ISSN:	1043-4666 1096-0023
DOI:	10.1006/cyto.1999.0637