Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside
The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2001, Vol.24(9), pp.1009-1011 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | MIURA, Toshihiro ICHIKI, Hiroyuki IWAMOTO, Naoki KATO, Motoshi KUBO, Masayoshi SASAKI, Hiroshi OKADA, Minoru ISHIDA, Torao SEINO, Yutaka TANIGAWA, Keiichiro |
| description | The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p |
| doi_str_mv | 10.1248/bpb.24.1009 |
| format | Article |
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The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.24.1009</identifier><identifier>PMID: 11558559</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Anemarrhena asphodeloides ; Animals ; antidiabetic activity ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - genetics ; Dose-Response Relationship, Drug ; General pharmacology ; Glucose Tolerance Test ; Glucosides - pharmacology ; Hypoglycemic Agents - therapeutic use ; KK-Ay mouse ; mangiferin ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Tolbutamide - pharmacology ; Xanthenes - pharmacology ; Xanthones</subject><ispartof>Biological and Pharmaceutical Bulletin, 2001, Vol.24(9), pp.1009-1011</ispartof><rights>2001 The Pharmaceutical Society of Japan</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-1f13cee7c94e2a776061ca3af9c382fc7774730f10191072b0d668bf6a5aa8ec3</citedby><cites>FETCH-LOGICAL-c653t-1f13cee7c94e2a776061ca3af9c382fc7774730f10191072b0d668bf6a5aa8ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14074570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11558559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIURA, Toshihiro</creatorcontrib><creatorcontrib>ICHIKI, Hiroyuki</creatorcontrib><creatorcontrib>IWAMOTO, Naoki</creatorcontrib><creatorcontrib>KATO, Motoshi</creatorcontrib><creatorcontrib>KUBO, Masayoshi</creatorcontrib><creatorcontrib>SASAKI, Hiroshi</creatorcontrib><creatorcontrib>OKADA, Minoru</creatorcontrib><creatorcontrib>ISHIDA, Torao</creatorcontrib><creatorcontrib>SEINO, Yutaka</creatorcontrib><creatorcontrib>TANIGAWA, Keiichiro</creatorcontrib><title>Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.</description><subject>Anemarrhena asphodeloides</subject><subject>Animals</subject><subject>antidiabetic activity</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Glucose Tolerance Test</subject><subject>Glucosides - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>KK-Ay mouse</subject><subject>mangiferin</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Tolbutamide - pharmacology</subject><subject>Xanthenes - pharmacology</subject><subject>Xanthones</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0UGL1DAUB_Aiiju7evIuBdGLdkzapElvOwzrurAiiJ7Da_qyzdAmNWmF9dObseMueEkI-b288P5Z9oqSLS2Z_NhO7bZkW0pI8yTb0IqJgpeUP802pKGyqCmXZ9l5jAdCiCBl9Tw7o5RzyXmzyZadm21nocXZ6nynZ_vLzve5N_ncY_6tt7_9CMfjzuEIIfToIIc49b7DwdsOYw6uWwsx3_tx8g7dHD_kX8DdWYPBur_iZo759bBoH1PRi-yZgSHiy9N-kf34dPV9_7m4_Xp9s9_dFrrm1VxQQyuNKHTDsAQhalJTDRWYRleyNFoIwURFDCW0oUSULenqWramBg4gUVcX2bv13Sn4nwvGWY02ahwGcOiXqASltWy4SPDNf_Dgl-DS3xRlLI2xqaVM6v2qdPAxBjRqCjZN5V5Roo5ZqJSFKpk6ZpH069ObSzti92hPw0_g7QlA1DCYAE7b-OgYEYwLktzl6g5xhjt8ABBSZgP-a9qsy7H3w5XuISh01R-POqjy</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>MIURA, Toshihiro</creator><creator>ICHIKI, Hiroyuki</creator><creator>IWAMOTO, Naoki</creator><creator>KATO, Motoshi</creator><creator>KUBO, Masayoshi</creator><creator>SASAKI, Hiroshi</creator><creator>OKADA, Minoru</creator><creator>ISHIDA, Torao</creator><creator>SEINO, Yutaka</creator><creator>TANIGAWA, Keiichiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside</title><author>MIURA, Toshihiro ; ICHIKI, Hiroyuki ; IWAMOTO, Naoki ; KATO, Motoshi ; KUBO, Masayoshi ; SASAKI, Hiroshi ; OKADA, Minoru ; ISHIDA, Torao ; SEINO, Yutaka ; TANIGAWA, Keiichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-1f13cee7c94e2a776061ca3af9c382fc7774730f10191072b0d668bf6a5aa8ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anemarrhena asphodeloides</topic><topic>Animals</topic><topic>antidiabetic activity</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Glucose Tolerance Test</topic><topic>Glucosides - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>KK-Ay mouse</topic><topic>mangiferin</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11558559</pmid><doi>10.1248/bpb.24.1009</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Anemarrhena asphodeloides Animals antidiabetic activity Biological and medical sciences Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Dose-Response Relationship, Drug General pharmacology Glucose Tolerance Test Glucosides - pharmacology Hypoglycemic Agents - therapeutic use KK-Ay mouse mangiferin Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plants, Medicinal - chemistry Tolbutamide - pharmacology Xanthenes - pharmacology Xanthones |
| title | Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside |
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