Robinlin: A novel bioactive homo-monoterpene from Robinia pseudoacacia L. (Fabaceae)

A bioactivity-directed fractionation of the ethanolic extracts of Robinia pseudoacacia L. (Fabaceae) afforded robinlin ( 1), a novel homo-monoterpene. The structure of 1 was elucidated by spectral analyses of the parent compound as well as its derivatives; 1 showed strong bioactivity in the brine sh...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-10, Vol.11 (19), p.2603-2606
Hauptverfasser:	Tian, Feifei, Chang, Ching-Jer, Grutzner, John B, Nichols, David E, McLaughlin, Jerry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Artemia - drug effects Biological and medical sciences Cell Survival - drug effects Drug Screening Assays, Antitumor Fabaceae - chemistry General pharmacology Humans Magnetic Resonance Spectroscopy Medical sciences Monoterpenes Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Terpenes - chemistry Terpenes - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	A bioactivity-directed fractionation of the ethanolic extracts of Robinia pseudoacacia L. (Fabaceae) afforded robinlin ( 1), a novel homo-monoterpene. The structure of 1 was elucidated by spectral analyses of the parent compound as well as its derivatives; 1 showed strong bioactivity in the brine shrimp lethality test (BST). A bioactivity-directed fractionation of the ethanolic extracts of Robinia pseudoacacia L. (Fabaceae) afforded robinlin ( 1), a novel homo-monoterpene. The structure of 1 was elucidated by spectral analyses of the parent compound as well as its derivatives; 1 showed strong bioactivity in the brine shrimp lethality test (BST).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00514-5