Isolated pancreatic amylase deficiency: Probable error in maturation

A boy with failure to thrive and isolated pancreatic amylase deficiency is described. Immunoprecipitation confirmed only salivary isoamylase in duodenal fluid at ages 20 and 33 months. Because normal pancreatic amylase messenger RNA was detected by reverse-transcriptase polymerase chain reaction in...

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Veröffentlicht in:	The Journal of pediatrics 2000-06, Vol.136 (6), p.844-846
Hauptverfasser:	Mehta, Devendra I., Wang, Hugh H., Akins, Robert E., Wang, Lisa, Proujansky, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - deficiency Biological and medical sciences Errors of metabolism Failure to Thrive - enzymology Failure to Thrive - etiology Humans Infant Male Medical sciences Metabolic diseases Miscellaneous hereditary metabolic disorders Pancreas - enzymology
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Beschreibung
Zusammenfassung:	A boy with failure to thrive and isolated pancreatic amylase deficiency is described. Immunoprecipitation confirmed only salivary isoamylase in duodenal fluid at ages 20 and 33 months. Because normal pancreatic amylase messenger RNA was detected by reverse-transcriptase polymerase chain reaction in the fluid, failure of the normal maturation of pancreatic amylase secretion may explain the deficiency.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(00)96936-1