Decreased platelet [ 3H]paroxetine binding sites in suicide attempters

Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([ 3H]Par), in a sample of 20 suicide attempters...

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Veröffentlicht in:Psychiatry research 2001-09, Vol.103 (2), p.125-131
Hauptverfasser: Marazziti, Donatella, Dell'Osso, Liliana, Rossi, Alessandra, Masala, Irene, Baroni, Stefano, Armani, Antonella, Giannaccini, Gino, Di Nasso, Elena, Lucacchini, Antonio, Cassano, Giovanni B
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Sprache:eng
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Zusammenfassung:Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([ 3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [ 3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(01)00281-5