In vivo hyperpolarized 129Xe NMR spectroscopy in tumors
The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in th...
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| Veröffentlicht in: | Magnetic resonance in medicine 2001-09, Vol.46 (3), p.586-591 |
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| container_title | Magnetic resonance in medicine |
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| creator | Wolber, Jan McIntyre, Dominick J.O. Rodrigues, Loreta M. Carnochan, Paul Griffiths, John R. Leach, Martin O. Bifone, Angelo |
| description | The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.1231 |
| format | Article |
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Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1231</identifier><identifier>PMID: 11550253</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological and medical sciences ; Contrast Media - pharmacokinetics ; Contrast media. Radiopharmaceuticals ; Female ; Fibrosarcoma - diagnosis ; Fibrosarcoma - pathology ; Humans ; hyperpolarized ; Image Enhancement ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Mice, Inbred C3H ; Miscellaneous. Technology ; Neoplasm Transplantation ; NMR ; Pharmacology. Drug treatments ; Prolactinoma - diagnosis ; Prolactinoma - pathology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Inbred WF ; spectroscopy ; tumor ; Tumor Cells, Cultured - pathology ; xenon ; Xenon Isotopes - pharmacokinetics</subject><ispartof>Magnetic resonance in medicine, 2001-09, Vol.46 (3), p.586-591</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1231$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1231$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1138146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11550253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolber, Jan</creatorcontrib><creatorcontrib>McIntyre, Dominick J.O.</creatorcontrib><creatorcontrib>Rodrigues, Loreta M.</creatorcontrib><creatorcontrib>Carnochan, Paul</creatorcontrib><creatorcontrib>Griffiths, John R.</creatorcontrib><creatorcontrib>Leach, Martin O.</creatorcontrib><creatorcontrib>Bifone, Angelo</creatorcontrib><title>In vivo hyperpolarized 129Xe NMR spectroscopy in tumors</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. © 2001 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Female</subject><subject>Fibrosarcoma - diagnosis</subject><subject>Fibrosarcoma - pathology</subject><subject>Humans</subject><subject>hyperpolarized</subject><subject>Image Enhancement</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Miscellaneous. Technology</subject><subject>Neoplasm Transplantation</subject><subject>NMR</subject><subject>Pharmacology. Drug treatments</subject><subject>Prolactinoma - diagnosis</subject><subject>Prolactinoma - pathology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Inbred WF</subject><subject>spectroscopy</subject><subject>tumor</subject><subject>Tumor Cells, Cultured - pathology</subject><subject>xenon</subject><subject>Xenon Isotopes - pharmacokinetics</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0N9PwjAQB_DGaATRxL_A7MH4NuyPtaWPhiiQABqi0fDSdF0Xqxub7YbOv94RUHy6h_vc5e4LwDmCfQQhvs5d3keYoAPQRRTjEFMRHYIu5BEMCRJRB5x4_wYhFIJHx6CDEKUQU9IFfLIK1nZdBK9NaVxZZMrZb5MECIsXE8xni8CXRleu8Loom8CugqrOC-dPwVGqMm_OdrUHnu5uH4fjcHo_mgxvpqFtb0AhS5WhKRR6YAhEnCJEBhpClsQ6jRI0iBmhRiUxZ4Iwbaii7UQaYw5jRVMakx642u4tXfFRG1_J3HptskytTFF7yTevMCxaeLGDdZybRJbO5so18vfVFlzugPJaZalTK239P0cGKGItC7fs02am2beh3CQt26TlJmk5W8w2de-tr8zXn1fuXTJOOJXP85GcTZcPy9GYSUx-AJqBfcg</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Wolber, Jan</creator><creator>McIntyre, Dominick J.O.</creator><creator>Rodrigues, Loreta M.</creator><creator>Carnochan, Paul</creator><creator>Griffiths, John R.</creator><creator>Leach, Martin O.</creator><creator>Bifone, Angelo</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>In vivo hyperpolarized 129Xe NMR spectroscopy in tumors</title><author>Wolber, Jan ; McIntyre, Dominick J.O. ; Rodrigues, Loreta M. ; Carnochan, Paul ; Griffiths, John R. ; Leach, Martin O. ; Bifone, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2591-6fae5f09c8e301751138c006dbcf4d18b635eadb76936ce5a56fafb270ba5f5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Female</topic><topic>Fibrosarcoma - diagnosis</topic><topic>Fibrosarcoma - pathology</topic><topic>Humans</topic><topic>hyperpolarized</topic><topic>Image Enhancement</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Miscellaneous. Technology</topic><topic>Neoplasm Transplantation</topic><topic>NMR</topic><topic>Pharmacology. Drug treatments</topic><topic>Prolactinoma - diagnosis</topic><topic>Prolactinoma - pathology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Inbred WF</topic><topic>spectroscopy</topic><topic>tumor</topic><topic>Tumor Cells, Cultured - pathology</topic><topic>xenon</topic><topic>Xenon Isotopes - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolber, Jan</creatorcontrib><creatorcontrib>McIntyre, Dominick J.O.</creatorcontrib><creatorcontrib>Rodrigues, Loreta M.</creatorcontrib><creatorcontrib>Carnochan, Paul</creatorcontrib><creatorcontrib>Griffiths, John R.</creatorcontrib><creatorcontrib>Leach, Martin O.</creatorcontrib><creatorcontrib>Bifone, Angelo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolber, Jan</au><au>McIntyre, Dominick J.O.</au><au>Rodrigues, Loreta M.</au><au>Carnochan, Paul</au><au>Griffiths, John R.</au><au>Leach, Martin O.</au><au>Bifone, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo hyperpolarized 129Xe NMR spectroscopy in tumors</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. 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| subjects | Animals Biological and medical sciences Contrast Media - pharmacokinetics Contrast media. Radiopharmaceuticals Female Fibrosarcoma - diagnosis Fibrosarcoma - pathology Humans hyperpolarized Image Enhancement Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred C3H Miscellaneous. Technology Neoplasm Transplantation NMR Pharmacology. Drug treatments Prolactinoma - diagnosis Prolactinoma - pathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred WF spectroscopy tumor Tumor Cells, Cultured - pathology xenon Xenon Isotopes - pharmacokinetics |
| title | In vivo hyperpolarized 129Xe NMR spectroscopy in tumors |
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