In vivo hyperpolarized 129Xe NMR spectroscopy in tumors

In vivo hyperpolarized 129Xe NMR spectroscopy in tumors

The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in th...

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Veröffentlicht in:Magnetic resonance in medicine 2001-09, Vol.46 (3), p.586-591
Hauptverfasser: Wolber, Jan, McIntyre, Dominick J.O., Rodrigues, Loreta M., Carnochan, Paul, Griffiths, John R., Leach, Martin O., Bifone, Angelo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Contrast Media - pharmacokinetics
Contrast media. Radiopharmaceuticals
Female
Fibrosarcoma - diagnosis
Fibrosarcoma - pathology
Humans
hyperpolarized
Image Enhancement
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred C3H
Miscellaneous. Technology
Neoplasm Transplantation
NMR
Pharmacology. Drug treatments
Prolactinoma - diagnosis
Prolactinoma - pathology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rats
Rats, Inbred WF
spectroscopy
tumor
Tumor Cells, Cultured - pathology
xenon
Xenon Isotopes - pharmacokinetics
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Zusammenfassung:The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.1231