Retinal degeneration under the effect of antibodies to recoverin

Serious changes in the retina, diagnosed as retinal degeneration and uveitis, are observed only in the presence of high titers of antibodies to recoverin (Ca2+-binding protein, a paraneoplastic antigen) in the blood of rabbits. Negligible changes in the retina of rabbits with low antibody titers are...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2001-04, Vol.131 (4), p.350-352
Hauptverfasser:	Bazhin, A V, Slepova, O S, Tikhomirova, N K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - immunology Antigens, Neoplasm - immunology Calcium-Binding Proteins - immunology Eye Proteins Hippocalcin Lipoproteins Nerve Tissue Proteins Rabbits Recoverin Retina - immunology Retina - pathology Retinal Degeneration - immunology Retinal Degeneration - pathology
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Beschreibung
Zusammenfassung:	Serious changes in the retina, diagnosed as retinal degeneration and uveitis, are observed only in the presence of high titers of antibodies to recoverin (Ca2+-binding protein, a paraneoplastic antigen) in the blood of rabbits. Negligible changes in the retina of rabbits with low antibody titers are detected only by cytohistochemical analysis of the retina. No changes in the retina develop in rabbits intravenously injected with antibodies to recoverin.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1017952102887