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The Saccharomyces cerevisiae gene SGS1 encodes a protein related to the human DNA helicases defective in Werner syndrome, Bloom syndrome and Rothmund-Thomson syndrome. Yeast cells lacking the Sgs1 helicase and a related helicase, Srs2, are inviable or grow extremely poorly. The growth defect can be...

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Veröffentlicht in:	Nature genetics 2000-06, Vol.25 (2), p.132-134
1. Verfasser:	Klein, Hannah L
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Bloom Syndrome - enzymology Bloom Syndrome - genetics Cancer Research Cell Division - genetics DNA helicase DNA Helicases - deficiency DNA Helicases - genetics DNA Helicases - metabolism DNA repair DNA Repair - genetics DNA replication DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fungal Proteins - genetics Fungal Proteins - metabolism Gene expression Gene Function Genes, Fungal - genetics Genes, Lethal - genetics Human Genetics Humans news-and-views Physiological aspects Rad51 Recombinase Recombination, Genetic - genetics RecQ Helicases Rothmund-Thomson syndrome Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Sequence Homology, Nucleic Acid SGS1 gene sgs1 helicase srs2 helicase Werner Syndrome - enzymology Werner Syndrome - genetics Yeasts
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Beschreibung
Zusammenfassung:	The Saccharomyces cerevisiae gene SGS1 encodes a protein related to the human DNA helicases defective in Werner syndrome, Bloom syndrome and Rothmund-Thomson syndrome. Yeast cells lacking the Sgs1 helicase and a related helicase, Srs2, are inviable or grow extremely poorly. The growth defect can be rescued by crippling the homologous recombination repair pathway, indicating that the essential function of these genes is related to recombination
ISSN:	1061-4036 1546-1718
DOI:	10.1038/75957