Integrin tyrosine phosphorylation in platelet signaling
The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots...
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| Veröffentlicht in: | Current Opinion in Cell Biology 2001-10, Vol.13 (5), p.546-554 |
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| container_end_page | 554 |
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| container_issue | 5 |
| container_start_page | 546 |
| container_title | Current Opinion in Cell Biology |
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| creator | Phillips, David R Prasad, KS Srinivasa Manganello, Jeanne Bao, Ming Nannizzi-Alaimo, Lisa |
| description | The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of β3-integrin signals. |
| doi_str_mv | 10.1016/S0955-0674(00)00250-7 |
| format | Article |
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| ispartof | Current Opinion in Cell Biology, 2001-10, Vol.13 (5), p.546-554 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport aIIbb3 Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - metabolism Blood Platelets - physiology GPIIb-IIIa Integrin beta3 Mice Molecular Sequence Data Myosins - metabolism Phosphorylation Phosphotyrosine - metabolism Platelet Adhesiveness Platelet Aggregation Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Platelet Membrane Glycoproteins - chemistry Platelet Membrane Glycoproteins - metabolism platelets Proteins - metabolism Shc Signaling Adaptor Proteins Signal Transduction signaling Src Homology 2 Domain-Containing, Transforming Protein 1 |
| title | Integrin tyrosine phosphorylation in platelet signaling |
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