Integrin tyrosine phosphorylation in platelet signaling

The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots...

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Veröffentlicht in:	Current Opinion in Cell Biology 2001-10, Vol.13 (5), p.546-554
Hauptverfasser:	Phillips, David R, Prasad, KS Srinivasa, Manganello, Jeanne, Bao, Ming, Nannizzi-Alaimo, Lisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport aIIbb3 Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - metabolism Blood Platelets - physiology GPIIb-IIIa Integrin beta3 Mice Molecular Sequence Data Myosins - metabolism Phosphorylation Phosphotyrosine - metabolism Platelet Adhesiveness Platelet Aggregation Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Platelet Membrane Glycoproteins - chemistry Platelet Membrane Glycoproteins - metabolism platelets Proteins - metabolism Shc Signaling Adaptor Proteins Signal Transduction signaling Src Homology 2 Domain-Containing, Transforming Protein 1
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Beschreibung
Zusammenfassung:	The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of β3-integrin signals.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/S0955-0674(00)00250-7