Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients : Clinical and genotypic predictors of virologic response

Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients : Clinical and genotypic predictors of virologic response

To determine the impact of prior nonnucleoside reverse transcriptase inhibitor (NNRTI) therapy, genotypic resistance, and other variables on response to efavirenz (EFV)- and adefovir dipivoxil (ADV)-based salvage therapy. Retrospective clinical cohort study. One university and one community-based HI...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2000-03, Vol.23 (3), p.221-226
Hauptverfasser: SHULMAN, N. S, ZOLOPA, A. R, PASSARO, D. J, MURLIDHARAN, U, ISRAELSKI, D. M, BROSGART, T. L, MILLER, M. D, VAN DOREN, S, SHAFER, R. W, KATZENSTEIN, D. A
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
adefovir
Adenine - analogs & derivatives
Adenine - therapeutic use
Adult
AIDS
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antiviral Agents - therapeutic use
Benzoxazines
Biological and medical sciences
Codon - genetics
Cohort Studies
Drug therapy
Drug Therapy, Combination
efavirenz
Female
Genotype
HIV
HIV Infections - drug therapy
HIV Infections - genetics
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Logistic Models
Male
Medical sciences
Middle Aged
Mutation
Organophosphonates
Oxazines - therapeutic use
Protease Inhibitors - therapeutic use
Retrospective Studies
Reverse Transcriptase Inhibitors - therapeutic use
Salvage Therapy
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
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Zusammenfassung:To determine the impact of prior nonnucleoside reverse transcriptase inhibitor (NNRTI) therapy, genotypic resistance, and other variables on response to efavirenz (EFV)- and adefovir dipivoxil (ADV)-based salvage therapy. Retrospective clinical cohort study. One university and one community-based HIV clinic. All 33 patients who were coenrolled in both the EFV and ADV expanded access programs. Patients received EFV 600 mg/day and ADV 120 mg/day in addition to other antiretroviral agents. HIV viral load (
ISSN:1525-4135
1944-7884
DOI:10.1097/00042560-200003010-00002