Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics.
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| Veröffentlicht in: | Nature medicine 2001-09, Vol.7 (9), p.987-989 |
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| container_title | Nature medicine |
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| creator | Jain, Rakesh K. |
| description | Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics. |
| doi_str_mv | 10.1038/nm0901-987 |
| format | Article |
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| issn | 1078-8956 1546-170X |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Angiogenesis Apoptosis Biomedical and Life Sciences Biomedicine Blood vessels Blood Vessels - drug effects Blood Vessels - pathology Cancer Research Cancer therapies Clinical Trials as Topic commentary Humans Infectious Diseases Metabolic Diseases Molecular Medicine Neoplasms - blood supply Neoplasms - therapy Neovascularization, Pathologic - drug therapy Neurosciences Publishing Radiation Tumors Vascular endothelial growth factor |
| title | Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy |
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