Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2001-09, Vol.7 (9), p.987-989
1. Verfasser:	Jain, Rakesh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Biomedical and Life Sciences Biomedicine Blood vessels Blood Vessels - drug effects Blood Vessels - pathology Cancer Research Cancer therapies Clinical Trials as Topic commentary Humans Infectious Diseases Metabolic Diseases Molecular Medicine Neoplasms - blood supply Neoplasms - therapy Neovascularization, Pathologic - drug therapy Neurosciences Publishing Radiation Tumors Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm0901-987