Sensitivity to Fas-Mediated Apoptosis Is Determined Below Receptor Level in Human Vascular Smooth Muscle Cells

Despite Fas expression, many cells resist Fas-induced apoptosis. Although differences in surface Fas expression can explain Fas resistance, multiple proteins below receptor level also inhibit Fas-induced apoptosis. To examine the mechanism of Fas resistance, we studied Fas-induced apoptosis in human...

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Veröffentlicht in:	Circulation research 2000-05, Vol.86 (10), p.1038-1046
Hauptverfasser:	Chan, Shiu-Wan, Hegyi, Laszlo, Scott, Stephen, Cary, Nathaniel R. B, Weissberg, Peter L, Bennett, Martin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Apoptosis - physiology Arteriosclerosis - metabolism Biological and medical sciences Carrier Proteins - metabolism Caspase 3 Caspase 8 Caspase 9 Caspases - metabolism Cells, Cultured Culture Media, Serum-Free Drug Resistance fas Receptor - metabolism fas Receptor - physiology Fas-Associated Death Domain Protein Fundamental and applied biological sciences. Psychology Heart Humans Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Signal Transduction Vertebrates: cardiovascular system
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Zusammenfassung:	Despite Fas expression, many cells resist Fas-induced apoptosis. Although differences in surface Fas expression can explain Fas resistance, multiple proteins below receptor level also inhibit Fas-induced apoptosis. To examine the mechanism of Fas resistance, we studied Fas-induced apoptosis in human medial vascular smooth muscle cells (VSMCs) from healthy coronary arteries. VSMCs showed marked heterogeneity to Fas-induced apoptosis, exhibiting both Fas-resistant (98.1±2.3% viable, n=4, P =NS) and Fas-sensitive (31.3±2.6% viable, n=3, P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.res.86.10.1038