Protocol renal allograft biopsies and the design of clinical trials aimed to prevent or treat chronic allograft nephropathy

The minimum sample size to perform a clinical trial aimed to modify the natural history of chronic allograft nephropathy (CAN) is very large. Since the presence of chronic tubulointerstitial damage in renal protocol biopsy specimens is an independent predictor of late outcome, we evaluated whether p...

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Veröffentlicht in:	Transplantation 2000-05, Vol.69 (9), p.1849-1855
Hauptverfasser:	SERON, D, MORESO, F, GRINYO, J. M, RAMON, J. M, HUESO, M, CONDOM, E, FULLADOSA, X, BOVER, J, GIL-VERNET, S, CASTELAO, A. M, ALSINA, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biopsy Chronic Disease Clinical Trials as Topic Graft Rejection - prevention & control Graft Rejection - therapy Graft Survival Humans Interstitial nephritis Kidney - pathology Kidney Diseases - prevention & control Kidney Diseases - therapy Kidney Transplantation - adverse effects Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Research Design Risk Factors Transplantation, Homologous Tubulopathies
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Zusammenfassung:	The minimum sample size to perform a clinical trial aimed to modify the natural history of chronic allograft nephropathy (CAN) is very large. Since the presence of chronic tubulointerstitial damage in renal protocol biopsy specimens is an independent predictor of late outcome, we evaluated whether protocol biopsies could facilitate the design of trials aimed to prevent or treat CAN. Two hundred eighty-two protocol biopsy specimens were obtained 3 months after transplantation in 280 patients with serum creatinine levels
ISSN:	0041-1337 1534-6080
DOI:	10.1097/00007890-200005150-00019