Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia
We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. Plasma glucose concentrations were acutely raised in 10 norma...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2000-05, Vol.101 (19), p.2247-2251 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2251 |
|---|---|
| container_issue | 19 |
| container_start_page | 2247 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 101 |
| creator | MARFELLA, R ESPOSITO, K GIUNTA, R COPPOLA, G DE ANGELIS, L FARZATI, B PAOLISSO, G GIUGLIANO, D |
| description | We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes.
Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (P |
| doi_str_mv | 10.1161/01.CIR.101.19.2247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71141881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>54910707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-7412fab32e7f99832eab5bd2601c6817361cb97ce88bb80fb00f0a765d3339d23</originalsourceid><addsrcrecordid>eNpdkEtLAzEUhYMoWh9_wIUEEXdTc5PJJHEnxRcIQrHrkMlkbGQmU5POov_elBYUV4d7-M7hchC6BDIFqOCOwHT2Op9CVlBTSktxgCbAaVmUnKlDNCGEqEIwSk_QaUpf-ayY4MfoBIgE4IpM0GLmox07s_bhE5tm6ZIfAu6HzmXXJewDXo69CQnf43l28dDi5Wbl4me3sa73BpvQ7Bwf0tj5sDXP0VFruuQu9nqGFk-PH7OX4u39-XX28FZYKmFdiBJoa2pGnWiVkllNzeuGVgRsJUGwCmythHVS1rUkbU1IS4yoeMMYUw1lZ-h217uKw_fo0lr3PlnXdSa4YUxaAJQgJWTw-h_4NYwx5N80BSo4r6TIEN1BNg4pRdfqVfS9iRsNRG8X1wR0XjyfoEHp7eI5dLVvHuveNX8iu4kzcLMHTLKma6MJ1qdfjlVc5p4f9kyIUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212755687</pqid></control><display><type>article</type><title>Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>MARFELLA, R ; ESPOSITO, K ; GIUNTA, R ; COPPOLA, G ; DE ANGELIS, L ; FARZATI, B ; PAOLISSO, G ; GIUGLIANO, D</creator><creatorcontrib>MARFELLA, R ; ESPOSITO, K ; GIUNTA, R ; COPPOLA, G ; DE ANGELIS, L ; FARZATI, B ; PAOLISSO, G ; GIUGLIANO, D</creatorcontrib><description>We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes.
Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (P<0.01) at 1 hour and returned to basal values at 2 hours. In another study, octreotide was infused during the hyperglycemic clamp to block the release of endogenous insulin; this prevented the late fall of plasma sICAM-l levels observed in under control clamp conditions. The diabetic patients had plasma sICAM-1 levels significantly higher (P<0.01) than those of the control subjects; plasma sVCAM-1 levels were similar. Both sICAM-l and sVCAM-1 concentrations did not change significantly during the control hyperglycemic clamp; however, octreotide infusion increased plasma sICAM-1 levels, which remained significantly (P<0.05) above baseline during the whole clamp. In an additional 10 type 2 diabetic patients, overnight euglycemia (plasma glucose 5.5 mmol/L) obtained with the aid of an artificial pancreas or supplementation with l-arginine (10 g PO for 30 days), the natural precursor of NO, normalized the increased plasma sICAM-1 levels.
Acute hyperglycemia increases circulating sICAM-1 levels in normal subjects, whereas the correction of hyperglycemia with insulin or l-arginine supplementation restored to normal levels the increased plasma sICAM-1 levels of type 2 diabetic patients.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.101.19.2247</identifier><identifier>PMID: 10811590</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Arginine - therapeutic use ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Circadian Rhythm ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Female ; Glucose Clamp Technique ; Humans ; Hyperglycemia - blood ; Hyperinsulinism - blood ; Intercellular Adhesion Molecule-1 - blood ; Male ; Medical sciences ; Middle Aged ; Reference Values ; Solubility ; Vascular Cell Adhesion Molecule-1 - blood</subject><ispartof>Circulation (New York, N.Y.), 2000-05, Vol.101 (19), p.2247-2251</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. May 16, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-7412fab32e7f99832eab5bd2601c6817361cb97ce88bb80fb00f0a765d3339d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1365847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10811590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARFELLA, R</creatorcontrib><creatorcontrib>ESPOSITO, K</creatorcontrib><creatorcontrib>GIUNTA, R</creatorcontrib><creatorcontrib>COPPOLA, G</creatorcontrib><creatorcontrib>DE ANGELIS, L</creatorcontrib><creatorcontrib>FARZATI, B</creatorcontrib><creatorcontrib>PAOLISSO, G</creatorcontrib><creatorcontrib>GIUGLIANO, D</creatorcontrib><title>Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes.
Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (P<0.01) at 1 hour and returned to basal values at 2 hours. In another study, octreotide was infused during the hyperglycemic clamp to block the release of endogenous insulin; this prevented the late fall of plasma sICAM-l levels observed in under control clamp conditions. The diabetic patients had plasma sICAM-1 levels significantly higher (P<0.01) than those of the control subjects; plasma sVCAM-1 levels were similar. Both sICAM-l and sVCAM-1 concentrations did not change significantly during the control hyperglycemic clamp; however, octreotide infusion increased plasma sICAM-1 levels, which remained significantly (P<0.05) above baseline during the whole clamp. In an additional 10 type 2 diabetic patients, overnight euglycemia (plasma glucose 5.5 mmol/L) obtained with the aid of an artificial pancreas or supplementation with l-arginine (10 g PO for 30 days), the natural precursor of NO, normalized the increased plasma sICAM-1 levels.
Acute hyperglycemia increases circulating sICAM-1 levels in normal subjects, whereas the correction of hyperglycemia with insulin or l-arginine supplementation restored to normal levels the increased plasma sICAM-1 levels of type 2 diabetic patients.</description><subject>Adult</subject><subject>Arginine - therapeutic use</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Circadian Rhythm</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Female</subject><subject>Glucose Clamp Technique</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Hyperinsulinism - blood</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Solubility</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMoWh9_wIUEEXdTc5PJJHEnxRcIQrHrkMlkbGQmU5POov_elBYUV4d7-M7hchC6BDIFqOCOwHT2Op9CVlBTSktxgCbAaVmUnKlDNCGEqEIwSk_QaUpf-ayY4MfoBIgE4IpM0GLmox07s_bhE5tm6ZIfAu6HzmXXJewDXo69CQnf43l28dDi5Wbl4me3sa73BpvQ7Bwf0tj5sDXP0VFruuQu9nqGFk-PH7OX4u39-XX28FZYKmFdiBJoa2pGnWiVkllNzeuGVgRsJUGwCmythHVS1rUkbU1IS4yoeMMYUw1lZ-h217uKw_fo0lr3PlnXdSa4YUxaAJQgJWTw-h_4NYwx5N80BSo4r6TIEN1BNg4pRdfqVfS9iRsNRG8X1wR0XjyfoEHp7eI5dLVvHuveNX8iu4kzcLMHTLKma6MJ1qdfjlVc5p4f9kyIUA</recordid><startdate>20000516</startdate><enddate>20000516</enddate><creator>MARFELLA, R</creator><creator>ESPOSITO, K</creator><creator>GIUNTA, R</creator><creator>COPPOLA, G</creator><creator>DE ANGELIS, L</creator><creator>FARZATI, B</creator><creator>PAOLISSO, G</creator><creator>GIUGLIANO, D</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20000516</creationdate><title>Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia</title><author>MARFELLA, R ; ESPOSITO, K ; GIUNTA, R ; COPPOLA, G ; DE ANGELIS, L ; FARZATI, B ; PAOLISSO, G ; GIUGLIANO, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-7412fab32e7f99832eab5bd2601c6817361cb97ce88bb80fb00f0a765d3339d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Arginine - therapeutic use</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Circadian Rhythm</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Female</topic><topic>Glucose Clamp Technique</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Hyperinsulinism - blood</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Solubility</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARFELLA, R</creatorcontrib><creatorcontrib>ESPOSITO, K</creatorcontrib><creatorcontrib>GIUNTA, R</creatorcontrib><creatorcontrib>COPPOLA, G</creatorcontrib><creatorcontrib>DE ANGELIS, L</creatorcontrib><creatorcontrib>FARZATI, B</creatorcontrib><creatorcontrib>PAOLISSO, G</creatorcontrib><creatorcontrib>GIUGLIANO, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARFELLA, R</au><au>ESPOSITO, K</au><au>GIUNTA, R</au><au>COPPOLA, G</au><au>DE ANGELIS, L</au><au>FARZATI, B</au><au>PAOLISSO, G</au><au>GIUGLIANO, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2000-05-16</date><risdate>2000</risdate><volume>101</volume><issue>19</issue><spage>2247</spage><epage>2251</epage><pages>2247-2251</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes.
Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (P<0.01) at 1 hour and returned to basal values at 2 hours. In another study, octreotide was infused during the hyperglycemic clamp to block the release of endogenous insulin; this prevented the late fall of plasma sICAM-l levels observed in under control clamp conditions. The diabetic patients had plasma sICAM-1 levels significantly higher (P<0.01) than those of the control subjects; plasma sVCAM-1 levels were similar. Both sICAM-l and sVCAM-1 concentrations did not change significantly during the control hyperglycemic clamp; however, octreotide infusion increased plasma sICAM-1 levels, which remained significantly (P<0.05) above baseline during the whole clamp. In an additional 10 type 2 diabetic patients, overnight euglycemia (plasma glucose 5.5 mmol/L) obtained with the aid of an artificial pancreas or supplementation with l-arginine (10 g PO for 30 days), the natural precursor of NO, normalized the increased plasma sICAM-1 levels.
Acute hyperglycemia increases circulating sICAM-1 levels in normal subjects, whereas the correction of hyperglycemia with insulin or l-arginine supplementation restored to normal levels the increased plasma sICAM-1 levels of type 2 diabetic patients.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10811590</pmid><doi>10.1161/01.CIR.101.19.2247</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2000-05, Vol.101 (19), p.2247-2251 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71141881 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Arginine - therapeutic use Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Circadian Rhythm Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Female Glucose Clamp Technique Humans Hyperglycemia - blood Hyperinsulinism - blood Intercellular Adhesion Molecule-1 - blood Male Medical sciences Middle Aged Reference Values Solubility Vascular Cell Adhesion Molecule-1 - blood |
| title | Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T20%3A47%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20adhesion%20molecules%20in%20humans%20:%20Role%20of%20hyperglycemia%20and%20hyperinsulinemia&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=MARFELLA,%20R&rft.date=2000-05-16&rft.volume=101&rft.issue=19&rft.spage=2247&rft.epage=2251&rft.pages=2247-2251&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.CIR.101.19.2247&rft_dat=%3Cproquest_cross%3E54910707%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212755687&rft_id=info:pmid/10811590&rfr_iscdi=true |