Circulating adhesion molecules in humans : Role of hyperglycemia and hyperinsulinemia

We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. Plasma glucose concentrations were acutely raised in 10 norma...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-05, Vol.101 (19), p.2247-2251
Hauptverfasser:	MARFELLA, R, ESPOSITO, K, GIUNTA, R, COPPOLA, G, DE ANGELIS, L, FARZATI, B, PAOLISSO, G, GIUGLIANO, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arginine - therapeutic use Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Circadian Rhythm Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Female Glucose Clamp Technique Humans Hyperglycemia - blood Hyperinsulinism - blood Intercellular Adhesion Molecule-1 - blood Male Medical sciences Middle Aged Reference Values Solubility Vascular Cell Adhesion Molecule-1 - blood
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Zusammenfassung:	We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.101.19.2247