Lymphocyte development from hematopoietic stem cells

The recent application of new techniques, such as multi-color cell sorting and the production of transgenic and gene-knockout mice, has contributed to a better understanding of lymphocyte development from hematopoietic stem cells. Now that we can purify progenitors at different maturational stages d...

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Veröffentlicht in:	Current Opinion in Genetics & Development 2001-10, Vol.11 (5), p.520-526
Hauptverfasser:	Kondo, Motonari, Scherer, David C, King, Angela G, Manz, Markus G, Weissman, Irving L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Lineage commitment cytokine receptor Dendritic Cells - cytology Gene Rearrangement - genetics hematopoietic stem cell Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Killer Cells, Natural - cytology Lymphocytes - cytology Lymphocytes - metabolism lymphopoiesis Receptors, Antigen - genetics Receptors, Cytokine - metabolism Signal Transduction transcription factor Transcription Factors - metabolism
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Zusammenfassung:	The recent application of new techniques, such as multi-color cell sorting and the production of transgenic and gene-knockout mice, has contributed to a better understanding of lymphocyte development from hematopoietic stem cells. Now that we can purify progenitors at different maturational stages during lymphocyte development, the challenge is to understand the processes that govern each developmental stage transition.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(00)00227-6