Long-circulating liposomes of indomethacin in arthritic rats — a biodisposition study

To improve the targeting efficiency of liposomes of indomethacin to the arthritic joints, circulation half-life of the liposomes was increased by grafting amphipathic polyethylene glycol-2000 to the bilayer surface. A comparative biodistribution study was performed between the conventional liposomes (PC:CH:PE — 1:0.5:0.16) and long-circulating liposomes (PC:CH:PE-PEG — 1:0.5:0.16) in arthritic rats. Pharmocokinetics of the drug changed significantly when administered in liposomal form. Pharmacokinetic parameters of the drug such as AUC0-t (trapezoidal), clearance and t1/2 (elimination half-life) changed significantly (p