Facile Three-Component Coupling Procedure for the Synthesis of Substituted Tetrahydroisoindole-1,3-diones from α,β-Unsaturated Aldehydes

A new one-pot procedure for the efficient synthesis of a small library of amino-functionalized tetrahydroisoindole-1,3-dione derivatives was developed. This three-component coupling reaction comprises subsequent condensation and Diels−Alder reactions of ubiquitous available starting materials (α,β-unsaturated aldehydes, amide, and maleimide). The synthesized compounds share a substituted tetrahydroisoindole motif in an endo fashion.