Jekyll and Hyde: the transformation of HLA-B27

HLA-B27 can adopt a homodimeric form. In spondyloarthritis, such aberrant expression of B27 may override a tissue-specific inhibition of major histocompatibility complex (MHC) class I-dependent events, leading to inflammation and fibrosis.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 2000-06, Vol.21 (6), p.256-260
Hauptverfasser:	Edwards, Jonathan C.W, Bowness, Paul, Archer, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Ankylosing spondylitis Antigen Presentation Arthritis, Psoriatic - genetics Arthritis, Psoriatic - immunology Arthritis, Reactive - genetics Arthritis, Reactive - immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology CD4-Positive T-Lymphocytes - immunology Crohn Disease - genetics Crohn Disease - immunology Cystine - chemistry Dimerization Fibrillins Genetic Predisposition to Disease histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology HLA-B27 HLA-B27 Antigen - chemistry HLA-B27 Antigen - genetics HLA-B27 Antigen - physiology Humans Lung - immunology Lung - pathology Lymphocyte Activation Marfan Syndrome - metabolism Mice Microfilament Proteins - deficiency Microfilament Proteins - metabolism Models, Immunological Organ Specificity Protein Conformation Rats Sacroiliac Joint - immunology Sacroiliac Joint - pathology Spondarthropathy Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - immunology Stress, Mechanical Transforming Growth Factor beta - physiology Uveitis, Anterior - genetics Uveitis, Anterior - immunology
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Beschreibung
Zusammenfassung:	HLA-B27 can adopt a homodimeric form. In spondyloarthritis, such aberrant expression of B27 may override a tissue-specific inhibition of major histocompatibility complex (MHC) class I-dependent events, leading to inflammation and fibrosis.
ISSN:	0167-5699
DOI:	10.1016/S0167-5699(00)01625-X