Blood glutathione and cysteine changes in cardiovascular disease

The need to investigate aminothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) in blood is stimulated by the current interest in hyperhomocysteinemia as a risk factor for atherosclerosis. Our current goal was to determine whether various cardiovascular (CV) diseases altered le...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of laboratory and clinical medicine 2000-05, Vol.135 (5), p.396-401
Hauptverfasser:	Mills, Betty Jane, Weiss, Morris M., Lang, Calvin A., Liu, Marcia C., Ziegler, Craig
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Arteriosclerosis - blood Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Urea Nitrogen Cardiology. Vascular system Case-Control Studies Creatinine - blood Cysteine - blood Cysteine - deficiency Cystine - blood Female Glutathione Disulfide - blood Glutathione Disulfide - deficiency Humans Male Medical sciences Middle Aged
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The need to investigate aminothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) in blood is stimulated by the current interest in hyperhomocysteinemia as a risk factor for atherosclerosis. Our current goal was to determine whether various cardiovascular (CV) diseases altered levels of GSH and Cys in blood and the relationships between these two thiols. Blood samples from 96 patients with atherosclerosis and other CV diseases were analyzed and compared with those from 33 control subjects. In CV patients, GSH levels were normal, but free plasma Cys was significantly higher (P
ISSN:	0022-2143 1532-6543
DOI:	10.1067/mlc.2000.105976