Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148: II. Physico-chemical Properties and Structure Elucidation

Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148: II. Physico-chemical Properties and Structure Elucidation

Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, a...

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Veröffentlicht in:Journal of antibiotics 2000/02/25, Vol.53(2), pp.163-170
Hauptverfasser: TAKAHASHI, SENJI, NAKANO, TAKAYUKI, KOIWA, TSUKASA, NOSHITA, TOSHIRO, FUNAYAMA, SHINJI, KOSHINO, HIROYUKI, NAKAGAWA, AKIRA
Format: Artikel
Sprache:eng
Schlagworte:
adxanthromycin A
adxanthromycin B
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Drug Evaluation, Preclinical
Fermentation
Fundamental and applied biological sciences. Psychology
General aspects
intercellular adhesion molecule 1
Intercellular Adhesion Molecule-1 - drug effects
Lymphocyte Function-Associated Antigen-1 - drug effects
Magnetic Resonance Spectroscopy
Microbiology
Molecular Structure
Peroxides - chemistry
Peroxides - pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Streptomyces
Streptomyces - chemistry
Streptomyces - metabolism
Xanthenes - chemistry
Xanthenes - pharmacology
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Zusammenfassung:Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing α-D-galactose by various NMR spectral analyses and chemical degradation.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.163