Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival

The quantitative assessment of apoptotic index (AI) and mitotic index (MI) and the immunoreactivity of p53, bcl‐2, p21, and mdm2 were examined in tumour and adjacent normal tissue samples from 30 patients with colonic and 22 with rectal adenocarcinoma. Individual features and combined profiles were...

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Veröffentlicht in:	The Journal of pathology 2001-08, Vol.194 (4), p.436-443
Hauptverfasser:	Elkablawy, Mohamed A., Maxwell, Perry, Williamson, Kate, Anderson, Neil, Hamilton, Peter W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Analysis of Variance Apoptosis bcl-2 Biological and medical sciences Biomarkers, Tumor - metabolism Cell Cycle Proteins - metabolism colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Immunophenotyping Male mdm2 Medical sciences Middle Aged mitosis Mitotic Index Neoplasm Proteins - metabolism Neoplasm Staging p21 p53 Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tumors
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Zusammenfassung:	The quantitative assessment of apoptotic index (AI) and mitotic index (MI) and the immunoreactivity of p53, bcl‐2, p21, and mdm2 were examined in tumour and adjacent normal tissue samples from 30 patients with colonic and 22 with rectal adenocarcinoma. Individual features and combined profiles were correlated with clinicopathological parameters and patient survival data to assess their prognostic value. Increased AI was significantly associated with increased bcl‐2 expression (p
ISSN:	0022-3417 1096-9896
DOI:	10.1002/path.894