Synthesis of d-labeled N-alkylmaleimides and application to quantitative peptide analysis by isotope differential mass spectrometry

d-Labeled N-alkylmaleimides have been prepared for specific modification of the terminal SH groups of cysteine residues in proteins or peptides. These reagents are useful tools for quantitative analysis of peptides by stable isotope differential mass spectrometry. d-Labeled N-alkylmaleimides have be...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-09, Vol.11 (17), p.2257-2261
Hauptverfasser:	Niwayama, Satomi, Kurono, Sadamu, Matsumoto, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Carbon Isotopes Diverse techniques Fundamental and applied biological sciences. Psychology Maleimides - chemical synthesis Molecular and cellular biology Molecular Sequence Data Peptides - analysis Peptides - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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Zusammenfassung:	d-Labeled N-alkylmaleimides have been prepared for specific modification of the terminal SH groups of cysteine residues in proteins or peptides. These reagents are useful tools for quantitative analysis of peptides by stable isotope differential mass spectrometry. d-Labeled N-alkylmaleimides have been prepared for specific modification of the terminal SH groups of cysteine residues in proteins or peptides. These reagents are useful tools for quantitative analysis of peptides by stable isotope differential mass spectrometry.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00452-8