A simple approach to DOTAP and its analogs bearing different fatty acids

A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]- N, N, N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemistry and physics of lipids 2000-04, Vol.105 (2), p.189-191
Hauptverfasser:	Massing, Ulrich, Kley, Jörg T., Gürtesch, Laura, Fankhaenel, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Cationic lipids Crystallization DOTAP Fatty Acids - chemistry Fatty Acids, Monounsaturated - chemical synthesis Fatty Acids, Monounsaturated - isolation & purification Fluorescent Dyes - chemical synthesis Fluorescent Dyes - isolation & purification Imidazolides Lipids - chemistry Magnetic Resonance Spectroscopy Quaternary Ammonium Compounds - chemical synthesis Quaternary Ammonium Compounds - isolation & purification Synthesis Transfection
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Beschreibung
Zusammenfassung:	A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]- N, N, N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.
ISSN:	0009-3084 1873-2941
DOI:	10.1016/S0009-3084(00)00121-3