Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors

HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E...

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Veröffentlicht in:	Microbes and infection 2000-04, Vol.2 (4), p.371-380
1. Verfasser:	O'Callaghan, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Antigens Antigens, CD - immunology Antigens, CD - metabolism Biological and medical sciences C-lectin CD94 Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology histocompatibility antigen HLA Histocompatibility antigens (hla, h-2 and other systems) Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism HLA Antigens - chemistry HLA Antigens - immunology HLA Antigens - metabolism HLA-E HLA-E Antigens immune recognition Killer Cells, Natural - immunology Lectins, C-Type Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Models, Immunological Molecular immunology NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D NK cells NKG2 Protein Sorting Signals - metabolism Qa-1b Qa-1b antigen Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, Natural Killer Cell
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Beschreibung
Zusammenfassung:	HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/S1286-4579(00)00330-0