Total Synthesis of (−)-Reveromycin B

Total Synthesis of (−)-Reveromycin B

The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence.

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Veröffentlicht in:Organic letters 2000-01, Vol.2 (2), p.191-194
Hauptverfasser: Cuzzupe, Anthony N, Hutton, Craig A, Lilly, Michael J, Mann, Robert K, Rizzacasa, Mark A, Zammit, Steven C
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemical synthesis
Epidermal Growth Factor - antagonists & inhibitors
Pyrans - chemical synthesis
Spiro Compounds - chemical synthesis
Stereoisomerism
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Zusammenfassung:The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol991281m