Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese

Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese

The GNB3 825C/T polymorphism, which is common worldwide, is associated with enhanced G-protein activation. The frequency of 825-T allele was increased with body mass index (BMI) and finally had a high frequency in relatively mild obese (BMI >27 kg/m(2)) subjects in some populations. In the presen...

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Veröffentlicht in:Biochemical and biophysical research communications 2001-08, Vol.286 (4), p.678-680
Hauptverfasser: Ohshiro, Y, Ueda, K, Wakasaki, H, Takasu, N, Nanjo, K
Format: Artikel
Sprache:eng
Schlagworte:
Body Mass Index
Diabetes Complications
Diabetes Mellitus - genetics
Diabetes Mellitus - pathology
Female
Gene Frequency
Heterotrimeric GTP-Binding Proteins - genetics
Humans
Japan
Male
Obesity - complications
Obesity - genetics
Obesity - pathology
Polymorphism, Single Nucleotide
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Zusammenfassung:The GNB3 825C/T polymorphism, which is common worldwide, is associated with enhanced G-protein activation. The frequency of 825-T allele was increased with body mass index (BMI) and finally had a high frequency in relatively mild obese (BMI >27 kg/m(2)) subjects in some populations. In the present study, we investigated 208 severely obese [BMI >or=30 kg/m(2) (97th percentile)] Japanese subjects including 146 probands with diabetes. No increase in the 825-T allele frequency was observed in the 208 severely obese and even in a subgroup of the 55 most obese [BMI >or=35 kg/m(2) (99.7th percentile)] subjects compared with that in 150 controls (BMI
ISSN:0006-291X