Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy

To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic...

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Veröffentlicht in:	Journal of diabetes and its complications 2001-09, Vol.15 (5), p.257-259
Hauptverfasser:	Yuuki, Takashi, Kanda, Tsugiyasu, Kimura, Yasutaka, Kotajima, Nobuo, Tamura, Jun'ichi, Kobayashi, Isao, Kishi, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Associated diseases and complications Biological and medical sciences Blood - metabolism Cytokine Cytokines - metabolism Diabetes. Impaired glucose tolerance Diabetic Retinopathy - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Humans Inflammation Mediators - metabolism Interleukin-6 - metabolism Interleukin-8 Interleukin-8 - metabolism Medical sciences Retinopathy Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Vitreoretinopathy, Proliferative - metabolism Vitreous Body - metabolism
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Zusammenfassung:	To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and 21 patients with vitreous noninflammatory retinopathies. Vitreous concentration of IL-6 were 64.7±12.8 pg/ml in proliferative diabetic retinopathy, much greater ( P
ISSN:	1056-8727 1873-460X
DOI:	10.1016/S1056-8727(01)00155-6